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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K6
All Species:
13.64
Human Site:
T315
Identified Species:
25
UniProt:
P52564
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52564
NP_002749.2
334
37492
T315
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
K362
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851023
334
37590
T315
L
M
Q
H
P
F
F
T
L
H
E
S
K
A
T
Cat
Felis silvestris
Mouse
Mus musculus
P70236
334
37414
T315
L
M
Q
H
P
F
F
T
V
H
E
S
K
A
A
Rat
Rattus norvegicus
Q4KSH7
419
47517
I380
K
L
L
E
H
S
F
I
K
H
Y
E
T
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511595
352
40240
N331
L
M
E
H
P
F
F
N
L
H
K
T
K
E
T
Chicken
Gallus gallus
Q90891
398
44059
K368
L
M
N
H
T
F
I
K
R
S
E
V
E
E
V
Frog
Xenopus laevis
Q07192
446
50082
P412
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
T342
L
M
Q
H
P
F
F
T
L
H
D
S
K
D
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477162
334
38176
V308
L
L
K
H
S
F
I
V
E
H
L
Q
R
N
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q20347
363
41178
Y330
T
L
K
S
F
D
F
Y
R
I
Y
A
V
A
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
N331
L
M
E
H
P
F
L
N
K
Y
D
Y
S
G
I
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
V624
L
T
E
H
P
W
L
V
K
Y
R
N
Q
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32
N.A.
98.8
N.A.
97.9
38.6
N.A.
75.2
34.4
43.5
80.6
N.A.
58.6
N.A.
38.2
N.A.
Protein Similarity:
100
47.8
N.A.
99
N.A.
99
53.7
N.A.
85.5
51.5
56
85.8
N.A.
74.8
N.A.
56.2
N.A.
P-Site Identity:
100
26.6
N.A.
93.3
N.A.
80
13.3
N.A.
66.6
33.3
0
86.6
N.A.
33.3
N.A.
6.6
N.A.
P-Site Similarity:
100
46.6
N.A.
93.3
N.A.
86.6
20
N.A.
86.6
40
6.6
93.3
N.A.
53.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
24.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.1
36
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
0
0
16
0
24
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
0
24
0
0
16
0
% D
% Glu:
0
0
31
8
0
0
0
0
8
0
31
8
16
31
16
% E
% Phe:
0
0
0
0
8
70
54
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
8
% G
% His:
0
0
0
77
8
0
8
0
0
54
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
24
8
0
16
0
0
0
0
8
% I
% Lys:
8
8
16
0
0
8
0
16
24
0
8
0
39
0
0
% K
% Leu:
77
24
8
8
8
0
16
0
31
0
16
0
0
8
0
% L
% Met:
0
62
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
16
0
0
0
8
0
8
0
% N
% Pro:
0
0
0
0
54
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
31
0
0
0
0
0
0
0
0
8
8
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
24
0
8
0
8
0
0
% R
% Ser:
0
0
0
8
8
8
0
0
0
16
0
31
8
0
0
% S
% Thr:
8
8
0
0
8
0
0
31
0
0
0
8
8
0
39
% T
% Val:
0
0
8
0
0
0
0
16
8
0
0
8
8
0
24
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
8
0
16
16
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _